Johannesburg – South Africa, is experiencing a surge in confirmed Mpox cases, prompting the Department of Health to issue a public notice urging vigilance.
Spokesperson Foster Mohale said on Thursday, 17 September 2026: “The Department of Health is urging citizens to remain vigilant of Mpox symptoms as the country is experiencing a rapid increase in laboratory-confirmed Mpox cases.”
He said that between 4 August this year and 17 September, South Africa had recorded as many as 18 laboratory-confirmed Mpox cases.
The department was also aware of one probable case.
Mohale said: “And this requires immediate and sustained public collaboration in order to contain further spread of this virus”.
Mohale said only one case was that of a female, and the rest were males.
Mohale said the 15 cases were recorded in Cape Town, Western Cape, three in Gauteng, and one in KwaZulu-Natal.
“Of concern is that 13 of the total cases were recorded between 13 August and 17 September,” said Mohale, adding that this suggests a rapid local transmission of this preventable viral infection.
He said the ages of the affected individuals range from 23 to 50 years.
“One of the most recent cases involved an individual who travelled to Spain earlier this month and returned to South Africa on 14 September revealed Mohale.
“This person underwent testing in Spain after being informed of his probable case status.
“South African health authorities are in are contact with the Spanish counterparts regarding laboratory test results of the individual to confirm his mpox status.”
Mpox cases may present in any person who was in close contact with someone who tested positive for the virus in the last few days (up to 21 days) and will present by displaying similar symptoms.
The importance of continued surveillance, early detection, and public cooperation cannot be overemphasised in preventing further transmission.
Mpox is a viral disease that can affect anyone regardless of race, gender, sexual orientation and socioeconomic status.
Members of the public are reminded of Mpox symptoms which include fever, headache, muscle aches, back pain, fatigue and rash or skin lesions that may appear on the face, hands, feet, genitals or other body parts.
Typically, the skin lesions start as flat red spots before progressing to bumps, followed by fluid-filled blisters, then pus filled bumps and eruptions into crusted scabs.
The symptoms usually appear within 6 to 13 days after exposure but can range from 5 to 21 days.
Therefore, anyone experiencing these symptoms, particularly if they have had close contact with a confirmed case or a suspected case, should seek medical attention immediately and avoid close contact with others.
Mpox is transmitted mainly through close physical contact with an infected person, including skin-to-skin contact with the rash or lesions, and contact with contaminated materials such as bedding, clothing, or towels used by an infected person.
Mpox-positive persons can also transmit the virus through respiratory droplets during prolonged face-to-face contact, uncovered coughing or sneezing.
“Vigilance remains essential, particularly in households, healthcare settings and among close social networks,” emphasised Mohale.
Hand hygiene through frequent washing or use of sanitisers is one of the effective methods to prevent the spread of the virus.
“The government, with support of the World Health Organization, has secured limited doses of mpox vaccines (MVA-BN) and treatment (Tecovirimat) as part of its outbreak response strategy to disrupt local transmission,” Mohale said.
“The health authorities will decide where and how to use these does to contain outbreaks.”
Vaccination should be accompanied by continued adherence to preventive measures.
Individuals and communities are urged to support those diagnosed with Mpox and those suspected of being infected with the virus, because stigma and discrimination have the potential to undermine an outbreak response by deterring people from seeking medical care.
For the latest updates on mpox, visit the NICD Disease Index mpox page and explore the dedicated mpox dashboard for regular updates.
