The South African Health Products Regulatory Authority (SAHPRA) on Monday revealed that a second fatal case of Guillain-Barré syndrome (GBS) had been reported following a Covid-19 vaccination.
SAHPRA reported the first fatal case of GBS in the country last month, on 4 August 2022,
The regulatory authority said it has been informed of a second fatal case of GBS following vaccination with the Covid-19 Vaccine Janssen.
“Causality assessment of the reported case was conducted by the National Immunisation Safety Expert Committee (NISEC) using the World Health Organizations (WHO) methodology,” explained SAHPRA in a statement issued by CEO Dr. Boitumelo Semete-Makokotlela.
“The case was classified as a vaccine product-related event following investigations conducted and causality assessment.
“The events reported in the vaccine recipient were consistent with the case definition of GBS and no other likely cause of GBS was identified at the time of illness.”
GBS is a very rare but potentially severe neurological adverse event that is associated with the administration of various vaccines and other medicines and can also be triggered by some bacterial or viral infections, including SARS-CoV-2.
Symptoms of GBS range from mild to severe, and may include muscle weakness, muscle pain, numbness, and tingling.
In many cases, GBS resolves with no serious after-effects, but in some cases GBS can cause serious or life-threatening problems.
Regulatory authorities have previously investigated reports of GBS associated with Covi-19 vaccines.
“They concluded that Covid-19 Vaccine Janssen may increase the risk of GBS,” said SAHPRA.
“GBS is therefore listed as a rare adverse event in the professional information (PI) for Covid-19 Vaccine Janssen.
“Investigations and causality assessment of all reported severe AEFI with the Covid-19 Vaccine Janssen and other Covid-19 vaccines are ongoing.”
However, SAHPRA said it was important to note:
Covid-19 vaccines have consistently been shown to prevent severe forms of disease, hospitalisation, and death.
Based on the currently available evidence, SAHPRA said it has determined that the benefits of Covid-19 vaccination far outweigh the very low risk of severe adverse events, including GBS.
“The public is strongly advised not to delay Covid-19 vaccination if eligible in terms of the national vaccination programme,” said the regulatory authority.
SAHPRA urged the public to report any suspected adverse events following the use of all medicines and vaccines.
Reporting can be done at a health facility or by downloading the Med Safety App (https://medsafety.sahpra.org.za/), which is available for Android and iOS phones, or by calling the Covid-19 hotline at 0800 029 999.
More information: https://aefi-reporting.sahpra.org.za/
